Sané is the son of former German rhythmic gymnast, the 1984 Summer Olympics bronze medalist Regina Weber and former footballer and Senegalese international Souleymane Sané. Souleymane Sané was raised in France; he came to Germany via his service in the French Army. Leroy Sané was born in Essen, North Rhine-Westphalia and raised near the Lohrheidestadion in Wattenscheid. He was named Leroy in honor of Claude Le Roy, former head coach of his father. Leroy has dual German and French citizenship.
Leroy Sané began playing football in 2001 for the youth team of SG Wattenscheid 09, for which his father played early in his career. In 2005, he joined Schalke 04. Three years later he moved to Bayer 04 Leverkusen. In 2011, returned to the youth academy (Nachwuchsleistungszentrum) of Schalke 04.
Sané was first called up to the Germany U21 team by youth coach Horst Hrubesch on 28 August 2015, for the friendly against Denmark and for the 2017 UEFA European Under-21 Championship qualifier against Azerbaijan. On 3 September 2015, Leroy Sané made his debut for the German U21 side in a 2–1 win at Stadion an der Lohmühle in Lübeck against Denmark and he was replaced after 73 minutes by Julian Brandt.
Sané received his first senior call up to the German national team on 6 November 2015 in a friendly against France. On 13 November 2015, Sané was substituted in the 61st-minute for Julian Draxler in a friendly match against France in Saint-Denis, in what would be a 2–0 defeat for the Germans.
Sané was selected by Germany boss Joachim Löw to represent the country at Euro 2016. He participated in one match, replacing Bastian Schweinsteiger on 79 minutes in Germany’s 2–0 semifinal defeat to France.
On 2 August 2016, Sané joined Manchester City, signing a five-year deal for a reported £37 million, with performance-related add-ons potentially making the fee £46.5 million from Schalke 04. He made his debut in a 1–2 win, in the Manchester derby, on 10 September. His first goal for City came in a 2–1 win against Arsenal at home in the Premier League. Following a spell out injured, Sané returned against Tottenham and scored in a 2–2 draw at the Etihad. In the following match, he scored for the third consecutive game as City won 3–0 away at Crystal Palace in the FA Cup.
On 13 April 2017, Sané was named as one of six players shortlisted for the PFA Young Player of the Year award.
On 9 September 2017, Sané scored his first two goals of the 2017–18 season in Manchester City’s 5–0 defeat of Liverpool at the City of Manchester Stadium. He scored his third goal of the season against Crystal Palace in their second 5–0 victory of the season.
In the month of October, Sane` scored a total of three (3) goals and provide 3 assist. Sané was named premier League players of the month of October.